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Publications

  1. Lou, M., Gilpin, M. E., Burger, S. K., Malik, A. M., Gawuga, V., Popovic, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134:12947-12957
    Transition State Analysis of Acid-Catalyzed Hydrolysis of an Enol Ether, Enolpyruvylshikimate 3-Phosphate (EPSP) (link)

  2. Lou, M., Burger, S. K., Gilpin, M. E., Gawuga, V., Capretta, A. & Berti, P. J. (2012) J. Am. Chem. Soc. 134: 12958-12969
    Transition State Analysis of Enolpyruvylshikimate 3-Phosphate Synthase (AroA)-Catalyzed EPSP Hydrolysis (link)

  3. Rob, T., Liuni, P., Gill, P. K., Zhu, S., Balachandran, N., Berti, P. J. & Wilson, D. J. (2012) Anal. Chem. 84: 3771-3779
    Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry (link)

  4. Jiang, S., Gilpin, M. E., Attia, M., Ting, Y.-L. & Berti, P. J. (2011) Biochemistry 50: 2205-2212
    Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp (link)

  5. Jackson, S. G., Zhang, F., Chindemi, P., Junop, M. S. & Berti, P. J. (2009) Biochemistry 48:11715-11723
    Evidence for Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions (link)

  6. Berti, P. J. & Chindemi, P. (2009) Biochemistry 48:3699-3707
    Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis (link)

  7. McCann, J. A. B. & Berti, P. J. (2008) J. Am. Chem. Soc. 130:5789-5797
    Transition State Analysis of the DNA Repair Enzyme MutY (link)

  8. McCann, J. A. B. & Berti, P. J. (2007) J. Am. Chem. Soc. 129:7055-7064
    Transition State Analysis of Acid-catalyzed dAMP Hydrolysis (link)

  9. Clark, M. E. & Berti, P. J. (2007) Biochemistry 46:1933-1940
    Enolpyruvyl Activation by Enolpyruvyl Shikimate 3-Phosphate Synthase (link)

  10. Zhang, F. & Berti, P. J. (2006) Biochemistry 45:6027-6037
    Phosphate Analogues as Probes of the Catalytic Mechanisms of MurA and AroA, Two Carboxyvinyl Transferases (link)

  11. Loncke, P. G. & Berti, P. J. (2006) J. Am. Chem. Soc. 128:6132-6140
    Implications of Protonation and Substituent Effects for C-O and O-P Bond Cleavage in Phosphate Monoesters (link)

  12. Berti, P. J. & McCann, J. A. B. (2006) Chem. Rev. 106:506-555
    Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer (link)

  13. Mizyed, S., Oddone, A., Byczynski, B., Hughes, D. W., & Berti, P. J. (2005) Biochemistry 44:4011-4017
    UDP-N-acetylmuramic acid (UDP-MurNAc) is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase) (link)

  14. Lee, J. K., Bain, A. D. & Berti, P. J. (2004) J. Am. Chem. Soc. 126:3769-3776
    Probing the Transition States of Four Glucoside Hydrolyses with 13C Kinetic Isotope Effects Measured at Natural Abundance by NMR Spectroscopy. (link)

  15. Byczynski, B., Mizyed, S. & Berti, P. J. (2003) J. Am. Chem. Soc. 125:12541-12550
    Non-enzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Control the Rate and Fate of Breakdown. (link)

  16. McCann, J. A. B. & Berti, P. J. (2003) J. Biol. Chem. 278:29587-29592
    Adenine Release is Fast in MutY-Catalyzed Hydrolysis of G:A and 8-oxo-G:A DNA Mismatches (link)

  17. Mizyed, S., Wright, J. E. I., Byczynski, B. & Berti, P. J. (2003) Biochemistry 42:6986-6995
    Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis (link)

  18. Berti, P. J., & Tanaka, K. S. E. (2002) Adv. Phys. Org. Chem. 37:239-314
    Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non-enzymatic Glycoside Hydrolysis and Transfer (link)

  19. Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122:6527-6534
    Transition State Analysis for Depurination of DNA by Ricin A-Chain

  20. Chen, X.-Y., Berti, P. J. & Schramm, V. L. (2000) J. Am. Chem. Soc. 122:1609-1617
    Ricin A-Chain: Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA

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  21. Berti, P. J. (1999) Methods Enzymol. 308:355-397
    Determining Transition States from Kinetic Isotope Effects

  22. Berti, P. J. & Schramm, V. L. (1999) Enzymatic Transition State Structures Constrained by Experimental Kinetic Isotope Effects in ACS Symposium Series No. 721/Transition State Modeling for Catalysis ; Trulhar, D. G., Morokuma, K., Eds.; American Chemical Society: Washington, D.C.; pp 473-488

  23. Scheuring, J., Berti, P. J. & Schramm, V. L. (1998) Biochemistry 37:2748-2758
    Pertussis Toxin: Transition State Structure for ADP-ribosylation of Recombinant Giα1 Subunits

  24. Berti, P. J., Blanke, S. R. & Schramm, V. L., (1997) J. Am. Chem. Soc. 119:12079-12088
    Transition State Structure for the Hydrolysis of NAD+ Catalyzed by Diphtheria Toxin

  25. Berti, P. J. & Schramm, V. L. (1997) J. Am. Chem. Soc. 119:12069-12078
    Transition State Structure of the Solvolytic Hydrolysis of NAD+