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Our lab studies enzymatic transition states. Enzymes catalyze reactions by binding more tightly to their transition states than anything else, up to 10²⁰ times tighter than their substrates or products. Once we have solved a transition state structure, we can design stable molecules that mimic its charge and shape, and thus create powerful inhibitors.

Enzymes perform all the chemical reactions that make life possible, which makes them interesting in their own right. There are also a lot of good reasons to inhibit enzymes, such as killing pathogenic bacteria with new antibiotics.