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Professor
Canada Research Chair
Bioanalytical Chemistry
Department
of
Chemistry
McMaster
University
Hamilton, Ont.,
Canada
L8S 4M1
Tel: (905)
525-9140,
ext. 27033
FAX:
(905) 527-9950
Figure
1: Nanoliter
Inhibition Assay on a Kinase Microarray
E-Mail: brennanj@mcmaster.ca
(Analytical
Chemistry, 2005, 77, 8013.)
Department
University
est
Research Interests:
Our goal is to develop
solid-phase
affinity-based
assays suitable for: 1) high-throughput screening of complex small
molecule
mixtures against immobilized protein targets and; 2) biosensing of
toxins and patogens. Our research
encompasses
the development of new sol-gel methods for protein
immobilization, evaluation
of entrapped protein performance, and the design of new devices
and
assay formats for sensing and HTS.
Areas of Expertise:
- Biocompatible Sol-Gel Processing
- Protein
Microarray Technologies
- Bioffinity Chromatography / Mass Spectrometry
- High Throughput Screening of Mixtures
- Time Resolved Fluorescence of Proteins
- Biosensors and
Bioactive Paper Products
Figure 2. Enzyme-Reactor/Mass Spectrometry system for high-throughput screening of compound mixtures.
(Analytical Chemistry, 2005, 77, 7512.)