publications



	Professor J. McNulty
	PUBLICATIONS

	77. Isolation of Flavonoids from the Heartwood and Resin of Prunus avium and some preliminary biological investigations. J. McNulty, J. J. Nair, E. Bollareddy, K. Keskar, A. Thorat, D. J. Crankshaw, A. Holloway, G. Khan, G.D. Wright, L. Ejim, Phytochemistry, 70, in press (2009).

	76. Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4. J. McNulty, J. J. Nair, M. Singh, D. J. Crankshaw, A. C. Holloway, Bioorg. & Med. Chem. Lett., 19 in press (2009).

	75. Aqueous Wittig reactions of semi-stabilized ylides. A straightforward synthesis of 1,3-dienes and 1,3,5-trienes. J. McNulty, P. Das, Tetrahedron Lett., 50, 5737 (2009).

	74. A Novel P,O-type phosphorinane ligand for the Suzuki-Miyaura cross-coupling of aryl chlorides, E. Ullah, J. McNulty, A. Robertson, Tetrahedron Lett., 50, 5599 (2009).

	73. Development of a one-pot method for the homologation of aldehydes to carboxylic acids. J. McNulty, P. Das, Tetrahedron, 65, 7794 (2009).

	72. Highly stereoselective and general synthesis of trans-stilbenes and alkenes by means of an aqueous Wittig reaction. J. McNulty, P. Das, Eur. J. Org. Chem., 4031 (2009)

	71. Selective Cytochrome P450 3A4 Inhibitory Activity of Amaryllidaceae Alkaloids. J. McNulty, J. J. Nair, M. Singh, D. J. Crankshaw, A. C. Holloway, J. Bastida, Bioorg. & Med. Chem. Lett., 19 3233 (2009).

	70. Structure-activity Studies on the Lycorine Pharmacophore: A Potent Inducer of Apoptosis in Human Leukemia Cells. J. McNulty, J. J. Nair, J. Bastida, S. Pandey, C. Griffin, Phytochemistry, 70, 913 (2009).

	69. Highly Stereoselective and General Synthesis of trans-Stilbenes, Alkenes and Conjugated Polyenes. J. McNulty, P. Das. United States Provisional Patent 61-167,960, filed, April 9th, (2009).

	68. A Synthesis of Sulfonamide Analogues of Platensimycin Employing a Palladium-mediated Carbonylation Strategy. J. McNulty, J. J. Nair, A. Capretta, Tetrahedron Lett., 50, 4087 (2009).

	67. Structure Activity Studies on the Crinane Alkaloid Apoptosis Indicuing Pharmacophore. J. McNulty, J. J. Nair, J. Bastida, S. Pandey, C. Griffin. Nat. Prod. Commun. 4, 483 (2009).

	66. Efficient Palladium Catalyzed Carbonylative Suzuki-Miyaura Cross-coupling reactions with bis(di-tert-butylphosphine)-o-xylene. J. McNulty, J. J. Nair, M. Sliwinski, A. Robertson, Tetrahedron Lett., 50, 2342 (2009).

	65. Stereoselective Wittig Olefination Reactions Employing a Novel ortho-P-Aryl Alkoxide Effect. J. McNulty, K. Keskar, Tetrahedron Lett., 49, 7054 (2008).

	64. A Direct Synthesis of Vinylphosphonium Salts from alpha-Trimethylsily Yldies and Non-enolizable Aldehydes. J. McNulty, P. Das, Chemistry, A European Journal, 14, 8469-8472 (2008).

	63. Direct formation of esters and amides from carboxylic acids using diethyl chlorophosphate in pyridine. J. McNulty, V. Krishnamoorthy, , A. Robertson , Tetrahedron Lett., 49, 6344-6347 (2008).

	62. Rapid and efficient entry to vinylsilanes from aldehydes employing a novel transmetalation-Peterson sequence. J. McNulty, P. Das, J. Chem. Soc., Chem. Comm., 1244 (2008).

	61. Synthesis and Biological Evaluation of Fully Functionalized seco-Pancratistatin Analogues. J. McNulty, J.J. Nair, C. Griffin, S. Pandey, J. Nat. Prod., 71, 357 (2008).

	60. An improved synthesis of alpha-phosphonoenamines based on a modified Peterson olefination. J. McNulty, P. Das, D. Gosciniak, Tetrahedron Lett. 49, 281 (2008).

	59. Synergy of Pancratistatin and Tamoxifen on breast cancer cells in
	inducing apoptosis by targeting mitochondria. P. Siedlakowski, A. McLachlan, C. Griffin, J. McNulty, S. Pandey, Cancer Biol. and Therap., 7, 376-384 (2008).

	58. Unusual Magnesium Chloride Catalyzed non-Evans anti-Aldol reactions on an Enolizable L-Threose Derivative. J. McNulty,* J.J. Nair, M. Sliwinski, L.E. Harrington, S. Pandey, Eur. J., Org. Chem., 5669 (2007).

	57. Efficient Carbonylation Reactions in Phosphonium Salt Ionic Liquids: Anionic Effects. J. McNulty,* J.J. Nair, A.J. Robertson, Organic Lett., 9, 4575 (2007).

	56. Discovery of the apoptosis-inducing activity and high accumulation of the butenolides Menisdaurilide and Aquilegiolide in Dicentra spectablis.
	J. McNulty,* J. J. Nair, J. Poloczek, N. H.Werstiuk, S. Pandey, Planta Medica, 73, 1543 (2007).

	55. Selective Cytotoxicity of Pancratistatin-related Natural Amaryllidaceae Alkaloids: Evaluation of the Activity of Two New Compounds. C. Griffin, N. Sharda, D. Sood, J. J. Nair, J. McNulty, S. Pandey,* Cancer Cell. Internat., 1-7 (2007).

	54. Selective Apoptosis-inducing activity of Crinum-type Amaryllidaceae alkaloids
	J. McNulty,* J.J. Nair, C. Codina, J. Bastida, S. Pandey, J. Gerasimoff, C. Griffin, Phytochemistry, 68, 1068 (2007).

	53. A Pronounced Anionic Effect in the Pd-catalyzed Buchwald-Hartwig Amination Reaction Revealed in Phosphonium Salt Ionic Liquids.
	J. McNulty,* S. Cheekoori, T.P. Bender, J.A. Coggan, Eur. J. Org. Chem., 1423 (2007).

	52. Activation of membrane-Fas-receptor associated caspase-3 and induction of apoptosis by Pancratistatin, a novel anti-cancer agent capable of selectively targeting leukemia cells. Carly Griffin, James McNulty, Caroline Hamm, and Siyaram Pandey, Apoptosis Cell Res. 93-109 (2007).

	51. Scope and Mechanistic Insights Into the use of Trihexyl(tetradecyl)phosphonium Bistriflimide: a Remarkably Selective Ionic Liquid Solvent for Substitution Reactions. J. McNulty,* J.J. Nair, S. Cheekoori, V. Larichev, A. Capretta, A.J. Robertson, Chemistry, A European Journal, 12, 9314 (2006).

	50. Phosphorinanes as Ligands for Palladium-Catalyzed Cross-Coupling Chemistry
	T. Brenstrum, J. Clattenburg, J. Britten, S. Zavorines, J. Dyck, A.J. Robertson, J. McNulty,* A. Capretta,* Organic Lett., 8, 103 (2006).

49. A Synthesis of 3-deoxy-dihydro-lycoricidine: Refinement of a Structurally Minimum Pancratistatin Pharmacophore.
J. McNulty, V. Larichev, S. Pandey, Bioorganic and Med. Chem. Lett., 15, 5315 (2005).

48. Application of Phosphonium Salts as Catalysts.
J. McNulty, Multiphase Homogeneous Catalysis, Vol. 2, pp 542-6, Wiley-VCH Pub., Weinheim, (2005).

47. Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis.
A.M. McLachlan, N. Kekre, J. McNulty, S. Pandey, Apoptosis, 10, 619 (2005).

46. Induction of Apoptotic Cell Death Specifically in Rat and Human Cancer Cells by Pancratistatin.
S. Pandey,* N. Kekre, J. McNulty, J. Naderi, Art. Cells, Blood Sub. & Biotech., 33, 279 (2005).

45. A Mild Esterification Process in Phosphonium Salt Ionic Liquid.
J. McNulty,* S. Cheekoori, J.J. Nair, V. Larichev., A. Capretta, A.J. Robertson, Tetrahedron Lett., 46, 3641 (2005).

44. Dimethylmalonyltrialkylphosphoranes: Probing the steric effect on phosphorus and its stereochemical consequence in esterification reactions of chiral secondary alcohols. J.Dyck, J.McNulty,* A.Capretta, V.Larichev, S.Zavorine, A.Robertson, J. Organomet. Chem. 690, 2548 (2005).

43. Pancratistatin causes early activation of caspase-3 flipping of phosphotidyl serine followed by rapid apoptosis specifically in human lymphoma cells.
S. Pandey,* N. Kekre, J. McNulty, J. Naderi, Cancer Chemotherapy and Pharmacology, 56, 29 (2005).

42. Phosphonium Salts as Room-Temperature Ionic Liquids in Organic Synthesis,
J. McNulty,* A. Capretta, S. Cheekoori, J.A.C. Clyburne, A.J. Robertson, Chemicca Oggi, 22 (11/12), 13 (2004).

41. Phospha-adamantanes as Ligands for Organopalladium Chemistry: Aminations of Aryl Halides.�
D.A. Gerritsma, T. Brenstrum, J. McNulty and A. Capretta,* Tetrahedron Lett., 45, 8319 (2004).

40. Phospha-adamantanes as Ligands for Palladium Catalyzed Cross-Coupling Chemistry: Library Synthesis, Characterization and Screening in the Suzuki Coupling of Alkyl Halides and Tosylates Containing b-Hydrogens with Boronic Acids and Alkylboranes.
T. Brenstrum, D. A. Gerristma, G.M. Adjabeng, C. S. Frampton, J. Britten, A. J. Robertson, J. McNulty, and A. Capretta. Journal of Organic Chemistry, 69, 7635 (2004)
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39. Heck Reactions of Aryl Halides in Phosphonium Salt Ionic Liquids: Library Screening and Applications.
D.A. Gerritsma, A. Robertson, J. McNulty and A. Capretta. Tetrahedron Letters, 45, 7629 (2004).

38. Palladium Complexes of 1,3,5,7-tetramethyl-2,4,8-Trioxa-6-Phenyl-6- Phospha-adamantane: Synthesis, Crystal Structure and Use in the Suzuki and Sonogashira Reactions and the �-Arylation of Ketones.
G. Adjabeng, T. Brenstrum, C.S. Frampton, A.J. Robertson, J. Hillhouse, J. McNulty, A. Capretta, J. Org. Chem., 69, 5082 (2004).

37. Solid-Phase Suzuki Cross-Coupling Reactions Using a Phosphine Ligand Based on a Phoshpa-adamantane Framework.
S.A. Ohnmacht, T. Brenstrum, K.H. Bleicher, J. McNulty, A. Capretta, Tetrahedron Lett., 45, 5661 (2004).

36. Antineoplastic Agents 491. Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine aand 4-Methylaaptamine.
G.R. Pettit, H. Hoffman, D.L. Herald, J. McNulty, A. Murphy, K.C. Higgs, E. Hamel, N.E. Lewin, L.V. Pearce, P.M. Blumberg, R.K. Pettit, J.C. Knight, J. Org. Chem., 69, 2251 (2004).

35. Antineoplastic Agents 380. Isolation and X-ray Crystal Structure Determination of Isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the Phosphate Prodrug Hystatin 1.
G.R. Pettit, H. Hoffman, J. McNulty, K.C. Higgs, A. Murphy, D.J. Molloy, D.L. Herald, M.D. Williams, R.K. Pettit, D.L. Doubek, J.N.A. Hooper, L. Albright, J.M. Schmidt, J.C. Chapuis, L. P. Tackett. J. Nat. Prod., 67, 506 (2004).

34. Regiocontrol in the NBS-Mediated Oxidative Radical Fragmentation of Benzilidene Acetals and its Mechanistic Implications.
J. McNulty, J. Wilson, A. Rochon, J. Org. Chem., 69, 563 (2004).

33. A Highly Efficient General Synthesis of Phosphine-Borane Complexes.
J. McNulty, Y. Zhou, Tetrahedron Lett., 45, 407 (2004).

32. Phosphonium Salt Catalyzed Carbonyl Addition Reactions.
J. McNulty, J. Dyck, V. Larichev, A. Capretta, A.J. Robertson, Lett. in Org. Chem., 1, 137 (2004).

31. The Role of Acyloxyphosphonium Ionas and Stereochemical Influence of Base in the Phosphorane-Mediated Esterification of Alcohols.
J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, Angew. Chem. Int. Ed., 42, 4051 (2003) [Angew. Chem. 115, 4185 (2003)].

30. Dimethylmalonyltrialkylphosphoranes: New general reagents for esterification Reactions Allowing Controlled Inversion or Retention of Configuration on Chiral Alcohols.
J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, J. Org. Chem., 68, 1597 (2003).

29. Novel Class of tertiary Phosphine Ligands based on a Phospha-adamantane Framework and use in the Suzuki Reaction of Aryl Halides Under Mild Conditions.
G. Adjabeng, T. Brenstrum, J. Wilson, C. Frampton, A.J. Robertson, J. Hillhouse, J. McNulty, A. Capretta, Org. Lett., 5, 953 (2003).

28. Lipase Catalyzed Stereoselective Resolution and Desymmetrization of Binapthols.
M. Juarez-Hernandez, D.V. Johnson, H.L. Holland, J. McNulty, A. Capretta, Tetrahedron Asymm., 14, 289 (2003).

27.Suzuki Cross-coupling Reactions of Aryl halides in phosphonium Salt Ionic Liquid Under Mild Conditions.
J. McNulty, A. Capretta, J. Wilson, J. Dyck, G. Adjabeng, A.J. Robertson, J. Chem. Soc., Chem. Commun., 1986 (2002).

26.A New Class of Phosphorane for Condensation Reactions.
J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, US and International patetnts pending; WO 2004/000778 A1.

25. On the Direct 2,3-Hydroxyl Group Differentiation of Tartaric Acid Esters.
J. McNulty, J. Mao, Tetrahedron lett., 43, 3857 (2002).

24. A New Structural Motif for Rigid C2-Symmetrical 1,2-Diamines Employing Double Intramolecular pi-Stacking.
J. McNulty, R. Mo, A. Capretta, C.S. Frampton, J. Chem. Soc., Chem. Commun., 2384 (2001).

23. Studies Directed Towards the Refinement of the pancratistatin Cytotoxic Pharmacophore.
J. McNulty, J. Mao, R. Gibe, R. Mo, S. Wolf, G.R. Pettit, D.L. Herald, M.R. Boyd, Bioorganic and Med. Chem. Lett., 11, 169 (2001).

22. Selective Addition of grignard Reagents to 2,3-O-isopropylidene-bis Weinreb tartaric Acid Amides.
J. McNulty, V. Grunner, J. Mao, Tetrahedron lett., 42, 5609 (2001).

21. Novel Chiral phosphines derived from Limonene: the Synthesis and Structure of 4,8-Dimethyl-2-phosphabicyclo[3.3.1]nonane.
A.J. Robertson, C. Bradaric, C.S. Frampton, J. McNulty, A. Capretta, Tetrahedron Lett., 42, 2609 (2001).

20. Synthetic Approaches to the Eudistomin Marine Alkaloids.
J. McNulty, I.W.J. Still, Current Org. Chem., 4, 121 (2000).

19. Stereoselective Oxidative Dimerization of (1R)-Camphor. A Short Synthesis of exo,exo'-3,3'-Biisoborneol.
J. McNulty, M.J. Millar, G. Bernardinelli, C.W. Jefford, J. Org. Chem., 64, 5312 (1999).

18. The Ultrasound Promoted Knoevenagel Condensation of Aromatic Aldehydes.
J. McNulty, J.A. Steere, S. Wolf, Tetrahedron lett., 39, 8013 (1998).

17. Diastereoselective Intramolecular Entry to Lycoricidine Alkaloids.
J. McNulty, R. Mo, J. Chem. Soc., Chem. Commun., 933 (1998).

16. Antineoplastic Agents. 362. Isolati x-ray crystal Structure of Dibromophakelstatin from the Indian Ocean Sponge Phakellia mauritiana.
G.R. Pettit, J. McNulty, D.L. Herald, D.L. Doubek, J. Chapuis, J.M. Schmidt, L.P. Tackett, M.R. Boyd., J. Nat. Prod., 60, 180 (1997).

15. Synthesis of Enantiomerically Pure Beta-Amino Acids from L- and D-aspartic Acids.
C.W. Jefford, J. McNulty,, in Enantioselective Synthesis of Beta-Amino Acids, pp 83-104, E. Juaristi (Ed), Wiley, New York (1997).

14. The Enantioselective Synthesis of Beta-Amino Acids Their Alpha-Hydroxy Derivatives and the N-Terminal Components of Bestatin and Microginin.
C.W. Jefford, J. McNulty, Z. Lu, J.B. Wang, Helvetica Chim. Acta., 79, 1203 (1996).

13. Selective Methylation and Stereoselective reduction of a beta-Carboline to a N(2)-Methyl-1,2,3,4-tetrahydro-Beta-Carboline.
J. McNulty, I.W.J. Still, Tetrahedron Lett., 36, 7965 (1995).

12. Associative Behavior and Diffussion Coefficients of Hydrophobically Modified Poly(N,N-dimethylacrylamides).
Y. Uemura, J. McNulty, P.M. Macdonald, Macromolecules, 28, 4150 (1995).

11. A Concise Enantioselective Synthessi of N-Morpholinosphingosines from D-Aspartic Acid.
C.W. Jefford, J. McNulty, Z. Lu, J. Chem. Soc., Chem. Commun., 123 (1995)

10. Formamadine as a Versatile Protecting Group for Primary Amines: A Mild Procedure for Hydrolytic Removal.
D. Toste, J. McNulty, I.W.J. Still, Synth. Commun., 24, 1617 (1994).

9. A Practical Synthesis of (2S,3R)-3-Amino-2-methylpentanoic Acid from L-Aspartic Acid.
C.W. Jefford, J. McNulty, Helvetica Chim. Acta., 77, 2142 (1994).

8. Diastereoselective Pictet-Spengler Reactions of L-(Boc)Phenylalaninal and L-(Boc)Prolinal: Biomimetic Syntheses of Eudistomin T and (-)-Woodinine.
J. McNulty, I.W.J. Still, J. Chem. Soc., Perkin Trans. 1, 1329 (1994).

7. Synthetic Approaches to the Eudistomins.
J. McNulty, Ph.D. Thesis, University of Toronto (1993).

6. A Simple High-Yielding Synthesis of N(Boc) Alpha-Amino Esters: Precursors for Alpha-Amino Aldehydes.
J. McNulty, I.W.J. Still., Synth. Commun., 22, 979 (1992).

5. Diastereoselective Pictet-Spengler Reactions of L-(Boc)Prolinal: A Biomimetic Synthesis of Eudistomins H and I and (-)-Woodinine.
J. McNulty, I.W.J. Still, Tetrahedron Lett., 32, 4875 (1991).

4. A Comment on Uniform Polymer Particles by Dispersion Polymerization in Alcohol.
A.J. Paine, J. McNulty, J. Polym. Sci.: Polym. Chem. Ed., 28, 2569 (1990).

3. Dispersion Polymerization of Styrene in Polar Solvents. 6. Influence of Reaction Parameters on Particle Size and Molecular Weight in Poly(N-vinylpyrrolidone)-Stabilized Reactions.
A.J. Paine, W. Luymes, J. McNulty, Macromolecules, 23, 3104 (1990).

2. The Total Synthesis of Eudistomins S and T.
J. McNulty, M.Sc. Thesis, University of Toronto (1989).

1. The Synthesis of Eudistomins S and T: Beta-carbolines from the Tunicate Eudistoma olivaceum.
I.W.J. Still, J. McNulty, Heterocycles, 29, 2057 (1989).



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