Recent Results Surface modified silicone elastomer
  Silicone Elastomer
Michael A. Brook
Professor 

Some recent examples of research in the Brook group
Functional organic sidechains are readily accessible by Click chemistry F. Gonzaga, G. Yu, M. A. Brook, Highly efficient derivatization of polysiloxanes via Click technology, Chem. Commun. 2009, 1730
Functional silicone by click chemistry
 External silicone interfaces can be modified with respect to surface roughness, hydrophilicity and biology, which affects compatibility in the local environment.  Chen, H., Brook, M. A., Sheardown, H. D., Chen, Y., Klenkler, B. A Generic Bioaffinity Surfaces, Bioconjugate Chemistry 2006, 17, 21-28.
Generic protein tethering to silicone surfaces
 Platinum in breast implants is not in an ionic form.  Brook, Michael A., Comments on Total Platinum Concentration and Platinum Oxidation States in Body Fluids, Tissue, and Explants from Women Exposed to Silicone and Saline Breast Implants by IC-ICPMS, Anal. Chem. 2006, 76, 5609-5611.
Michael A. Brook, Platinum in Silicone Breast Implants, Biomaterials, 2006, 27, 3274-86
Proteins can remain natured in the presence of silicones. Paul M. Zelisko, Aimé Lopez Aguilar, and Michael A. Brook, Delivery of both active enzyme and bleach from water-in-silicone oil (D4) emulsions, Langmuir, 2007, 23, 3620-3625.
Bleach and proteins are both stable in silicones
Drug release from silicones is controlled by internal structuring Michael A. Brook, Alison C. Holloway, Kenneth K. Ng, Michael Hrynyk, Carly Moore, and Ryan Lall, Using a Drug to Structure Its Release Matrix and Release Profile, International Journal of Pharmaceutics 2008, 358,121-127 
Silicone elastomer drug delivering surface

 

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Last revision: 2009-08-22; mab © 1998-2009, M. Brook